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Copeptin: a marker for ADPKD progression?
Autosomal dominant polycystic kidney disease (ADPKD) accounts for ∼5–10% of patients with end-stage renal disease (ESRD) [1]. Mutations in the PKD1 and PKD2 gene, encoding polycystin-1 (PC-1) and -2 (PC-2), account for ∼85 and 15% of diseases, respectively. PC-1 interacts with PC-2 to build a multifunctional signalling complex that regulates intracellular Ca signalling, and epithelial developme...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2000
ISSN: 0003-4967
DOI: 10.1136/ard.59.8.654c